Rampage is a science fiction action film based on the 1986 arcade video game of the same name. The movie follows Dr. David Woz (Dwayne Johnson), a primatologist who works at the San Diego Wildlife Sanctuary. David's friend, Dr. Lyle Langston (Jeffrey Dean Morgan), has been experimenting on genetically enhanced animals to help cure diseases. However, when a strange virus is introduced, the animals begin to grow in size and become violent.