The film takes place in the 1970s, during the Vietnam War. A team of scientists and soldiers, led by Bill Randa (Tom Hiddleston), embark on an expedition to a remote island in the Pacific, known as Skull Island. The team, which includes entomologist Dr. Lin (Ziyi Zhang), photographer Mark Davis (John Goodman), and soldier Jack Driscoll (Samuel L. Jackson), aims to explore the island and uncover its secrets.